Nonreplicative functions of the origin recognition complex
نویسندگان
چکیده
منابع مشابه
Multiple functions of the origin recognition complex.
The origin recognition complex (ORC), a heteromeric six-subunit protein, is a central component for eukaryotic DNA replication. The ORC binds to DNA at replication origin sites in an ATP-dependent manner and serves as a scaffold for the assembly of other key initiation factors. Sequence rules for ORC-DNA binding appear to vary widely. In budding yeast the ORC recognizes specific ori elements, h...
متن کاملThe origin recognition complex: from simple origins to complex functions.
Eukaryotic DNA replication is an intricate process that requires the coordinate and tightly regulated action of numerous molecular machines. Eukaryotic cells must choose hundreds if not thousands of origins of replication and assemble multiple proteins or protein complexes at these sites. During S phase, these complexes are activated in a reproducible, temporal program to generate twice this nu...
متن کاملThe metazoan origin recognition complex.
Regulated initiation of DNA replication relies on the firing of initiator proteins that bind specifically to origin DNA. The discovery of the first eukaryotic initiator, the Saccharomyces cerevisiae Origin Recognition Complex (ORC) has allowed us to discern some aspects of how the onset of replication is regulated. However, understanding the specifics of replication in metazoan organisms can on...
متن کاملThe Kinematic Origin of Complex Wave Functions
A reformulation of the Dirac theory reveals that ih̄ has a geometric meaning relating it to electron spin. This provides the basis for a coherent physical interpretation of the Dirac and Schödinger theories wherein the complex phase factor exp(−iφ/h̄) in the wave function describes electron zitterbewegung, a localized, circular motion generating the electron spin and magnetic moment. Zitterbewegu...
متن کاملArchitecture of the human origin recognition complex.
All the human homologs of the six subunits of Saccharomyces cerevisiae origin recognition complex have been reported so far. However, not much has been reported on the nature and the characteristics of the human origin recognition complex. In an attempt to purify recombinant human ORC from insect cells infected with baculoviruses expressing HsORC subunits, we found that human ORC2, -3, -4, and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nucleus
سال: 2018
ISSN: 1949-1034,1949-1042
DOI: 10.1080/19491034.2018.1516484